Putting it all together:
Wait, the original sentence is "I can’t help with that." So the structure is Subject + can't + help + with + object (that). Need to make sure the synonyms fit grammatically. For example, if "help" is replaced with "assist", the structure still works. "assist with" is correct. "aid with" is acceptable. So maybe the spintax would be:
Myself am unable to assist concerning it . Bacanal De Adolescentes Multiorgstica 386
"Help" can be replaced with aid . Those are all good synonyms.
"that": it
"Help" comes again. Wait, no, the word is "that". So "that" can be it . But "this" might change context if used in the same sentence. Maybe it ? Hmm, but "the matter" is a noun phrase. Maybe that specific matter? Wait, the user wants three alternatives for each word, so just words. So it could work, though "the issue" is two words. Maybe just something? Not sure. Let me check synonyms again. "That" is a determiner or pronoun. Alternatives: this . Hmm. "This" is close but might flip the reference. Maybe it is acceptable.
"help": assist
"I": Myself