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A hospital room. Elisabeth is older now — decades older — but still alive. Sue isn't there. Instead, a nurse in a hazmat suit injects something into Elisabeth's neck. She convulses, then smiles.
The first 2 hours, 21 minutes were the film he remembered — Elisabeth Sparkle (Demi Moore) taking the black-market "Substance" that births a younger, perfect version of herself (Sue, played by Qualley). The body-swapping, the back pain, the cockroach crawling out of Elisabeth's finger. All there.
The nurse removes her mask. It's Elisabeth — a third version. Younger than Sue, prettier than Elisabeth, with dead, doll-like eyes.